It's necessary to be slightly underemployed if you are to do something significant.

Today, the theory of evolution is an accepted fact for everyone but a fundamentalist minority, whose objections are based not on reasoning but on doctrinaire adherence to religious principles.

Science moves with the spirit of an adventure characterized both by youthful arrogance and by the belief that the truth, once found, would be simple as well as pretty.

It's necessary to be slightly underemployed if you are to do something significant.

Take young researchers, put them together in virtual seclusion, give them an unprecedented degree of freedom and turn up the pressure by fostering competitiveness.

I think the reason people are dealing with science less well now than 50 years ago is that it has become so complicated.

One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid.

Biology has at least 50 more interesting years.

'Genes, Girls, and Gamow' was an attempt, even more than 'The Double Helix,' to mix science with one's personal life. With 'The Double Helix,' no one had done it before, but I thought I'd try.

An idea can be tested, whereas if you have no idea, nothing can be tested and you don't understand anything. The molecule that you make when you are getting sunburned or when you eat a lot of food is part of the same molecule that contains an endorphin or an opiate. No one has ever had a hypothesis about why the two are together.

As an educator, I have always striven to see that the fruits of the American Dream are available to all.

By the age of 11, I was no longer going to Sunday Mass, and going on birdwatching walks with my father. So early on, I heard of Charles Darwin. I guess, you know, he was the big hero. And, you know, you understand life as it now exists through evolution.

Genetically modified foods are good.

Great wealth could make an enormous difference over the next decade if they sensibly support the scientific elite. Just the elite. Because the elite makes most of the progress. You should worry about people who produce really novel inventions, not pedantic hacks.

Here at the Cold Spring Harbor Laboratory, we have genetically rearranged various viruses and bacteria as part of our medical research. In fact, we have been able to create entirely new types of DNA molecules by splicing together the genetic information from different organisms - recombinant DNA.

I am thrilled to see my genome.

I do think one success of Northern Europe, which the United States came from, was its willingness to accept innovation in business practices like Adam Smith and the whole Enlightenment. It essentially made the merchant class free instead of controlled by the king and aristocracy. That was essential.

I first became aware of Charles Darwin and evolution while still a schoolboy growing up in Chicago. My father and I had a passion for bird-watching, and when the snow or the rain kept me indoors, I read his bird books and learned about evolution.

I have a son, who is a... not an ordinary form of schizophrenia, but clearly, cannot take care of himself. And the great fear of then, of all parents is, when the parents die, who takes care of your child? And the answer is: they become homeless.

I have an odd theory on happiness, and it bothers people. My general theory is that happiness is a reward for an animal doing what it should be doing. So if a horse runs, it feels happy. Or if you are too thin, you can't be happy, because evolution wants you to be tense and anxious, trying to wake up in the morning looking for food.

I have been much blessed.

I have never seen Francis Crick in a modest mood. Perhaps in other company he is that way, but I have never had reason so to judge him.

I never could read science fiction. I was just uninterested in it. And you know, I don't like to read novels where the hero just goes beyond what I think could exist. And it doesn't interest me because I'm not learning anything about something I'll actually have to deal with.

I never dreamed that in my lifetime my own genome would be sequenced.

I never wanted to be liked by the majority of people, but there were always some people that I desperately wanted to be liked by. And so you've got to behave in a way that... the way I put it is that if you want to be a real intellectual, you've got to have someone to save you.

I wanted to see if I could write a good book.

I was always very curious about what a scientist's life was like when I was young. Of course, when I was young, you didn't have very many opportunities to find out with no web, TV. I was very lucky: I was born in the city of Chicago and went to the University of Chicago where I actually saw things.

I would only once have the opportunity to let my scientific career encompass a path from the double helix to the three billion steps of the human genome.

I've had strong opinions probably since I was born. It makes you unpopular, but what can you do?

If someone's liver doesn't work, we blame it on the genes; if someone's brain doesn't work properly, we blame the school. It's actually more humane to think of the condition as genetic. For instance, you don't want to say that someone is born unpleasant, but sometimes that might be true.

If we could honestly promise young couples that we knew how to give them offspring with superior character, why should we assume they would decline? Common sense tells us that if scientists find ways to greatly improve human capabilities, there will no stopping the public from happily seizing them.

If you accept that people are the products of evolution, then you have to have an open mind to the truth. Unfair discrimination exists whether we like it or not; I wouldn't have married a gum-chewing vegetarian.

If you go into science, I think you better go in with a dream that maybe you, too, will get a Nobel Prize. It's not that I went in and I thought I was very bright and I was going to get one, but I'll confess, you know, I knew what it was.

If you succeed with your first dream, it helps. You know, people trust you, possibly, for the second one. They give you a chance to play out your second one.

It's so difficult writing about living people.

My heroes were never scientists. They were Graham Greene and Christopher Isherwood, you know, good writers.

My parents made it clear that I should never display even the slightest disrespect to individuals who had the power to let me skip a half grade or move into more challenging classes. While it was all right for me to know more about a topic than my sixth-grade teacher had ever learned, questioning her facts could only lead to trouble.

My whole life has been basically trying to find intelligent students or, you know, highly motivated students and giving them an opportunity to do good science.

My wife and I have a schizophrenic son. We didn't want to accept this for 30 years, so we put him under great pressure when we shouldn't have. He just wanted to be looked after, and we didn't respect that. We tried to make him independent.

One-third of all female infertility is the result of blocked fallopian tubes. If fertilization could be done in the lab and then the fertilized egg implanted in the womb, it would get around that problem. Millions of women who cannot have children would suddenly be able to.

Our goal should be to understand our differences.

Science has always been my preoccupation and when you think a breakthrough is possible, it is terribly exciting.

Some think there is something wrong about enhancing people.

The ever quickening advances of science made possible by the success of the Human Genome Project will also soon let us see the essences of mental disease. Only after we understand them at the genetic level can we rationally seek out appropriate therapies for such illnesses as schizophrenia and bipolar disease.

The luckiest thing that ever happened to me was that my father didn't believe in God, and so he had no hang-ups about souls.

The pace of discovery is going unbelievably fast.

There are many people of color who are very talented.

To all those who have drawn the inference from my words that Africa, as a continent, is somehow genetically inferior, I can only apologise unreservedly.

Ultimately, we'll help the people we discriminate against if we try to understand more about them; genetics will lead to a world where there is a sympathy for the underdog.