FILAMENT INTERMÉDIAIRE Structure: - filamenteux ATTENTION, les monomères sont variables selon les cellules. — Polymérisation: Les étapes. 1. Formation de dimère superenroulés 2. Association de deux dimères: tétramère 3. Tétramères à bout: protofilament 4. 8 protoF = Fi

Généralités: - Cytosquelette s’étend dans la cellule de la membrane plasmique jusqu'au niveau de la face interne du noyau. - Composé de trois structures protéiques: microfilaments d’actine, filaments intermédiaires et microtubules.

MICROFILAMENT D'ACTINE Structure: - globulaire (actine G) - sillon chargé négativement ==> lien avec ATP - plus petit diamètre (5-8nm)

MICROTUBULES Structure: - globulaire - tubuline alpha et beta. - association avec GTP - plus grand diamètre (25nm)

I woke up one morning with this song in my head, and the opening line of the song is, 'My name was Richard Nixon, only now I'm a girl.'

I like being able to go to a local pub and have great food and particularly love pubs that welcome my dogs.

That's the definition of popularity. Something that literally resonates with many, many people.

I always wanted to be a superhero.

I will always vote on the side of freedom and our right to keep and bear arms.

Concentration camps were entirely a matter for the police and had nothing to do with the administration.

People used to pooh-pooh the idea of a check-in, saying that this wasn't interesting. But when you have 3 billion of those data points, you can take any latitude and longitude anywhere in the world, and I'll tell you what is interesting now, 20 minutes from now, and 6 hours from now.

There's a stigma that guys hate romance and hate love, but that's not true. Look at 'Iron Man.' There's a whole through-line plot about his relationship with Pepper, and everybody loves it.

It starts with campaign finance reform.

You can be chased home or hit or called names or spit on, and it's over. You have the memory of it, but it's very different from the emotional and psychological experience of feeling invisible, of not learning the confidence to stand up in class and speak.

While I was busy hating Vegas, and hiding from Vegas, a funny thing happened. I grew to love Vegas.

I drag myself out of nightmares each morning and find there's no relief in waking.

In Italy it's full-on stardom when you're a cyclist - eating in restaurants for free, it's great.

The best history is but like the art of Rembrandt; it casts a vivid light on certain selected causes, on those which were best and greatest; it leaves all the rest in shadow and unseen.

I got a job with a law firm in Portland after a couple of years with Senator Muskie. But by then, my interest in politics had been sparked, through meeting Senator Muskie, through seeing what he did.

In 1975, I quit my tenure, and we moved from Ann Arbor to New Hampshire. It was daunting to pay for groceries and the mortgage by freelance writing - but it worked, and I loved doing it.

My secret is simple. I have a very short attention span, and writing lots of things fast appeases that very attention span.

Where I live, nobody who's fourteen is having sex and doing major drugs. And I think if you see it in the movies, you may be influenced by it. I think it's so important to preserve your innocence.

You can write anything you want on paper, like blowing up the bridge on the River Kwai, but when you actually have to do that as a director, it's not the same. Ninety percent of directing is not creative - it's putting the theoretical into the practical world.

Happiness is having a large loving caring close knit family in another city.

I have always said that we did not expect a revolution in the streets.

We demand that people don't deny the Holocaust, and we can't ignore the tragedy of another nation.

'Hound Dog' took like twelve minutes. That's not a complicated piece of work. But the rhyme scheme was difficult. Also the metric structure of the music was not easy. 'Kansas City' was maybe eight minutes, if that. Writing the early blues was spontaneous. You can hear the energy in the work.

Lynch is an ordinary, smalltown guy and he just sees strange things in people.