Here's to alcohol: the cause of, and answer to, all of life's problems.

When authorities warn you of the sinfulness of sex, there is an important lesson to be learned. Do not have sex with the authorities.

When The Simpsons came around, there really was nothing else like it on TV. It's hard to imagine, but when Fox first took the plunge with it, it was considered controversial to put animation on prime time.

Don't have a cow, man.

A lot of our writers, like Conan O'Brien, moved on to other things.

A lot of people believe that if everybody just did what they were told - obeyed - everything would be fine. But that's not what life is all about. That's not real. It's never going to happen.

Since I was there in the very beginning, I know the history of the characters. So, I make comments about the tone and sometimes remind the writers that we've done that before.

Basically, everything I try to do is to present an alternative to what somebody else is doing.

The Simpsons is an especially collaborative show.

One of the things I would like to do is make up stories that I would have enjoyed when I was a kid. So, if I'm thinking about an audience, it's usually a younger version of myself.

Living creatively is really important to maintain throughout your life. And living creatively doesn't mean only artistic creativity, although that's part of it. It means being yourself, not just complying with the wishes of other people.

We've got a bunch of new writers now who tell me they grew up watching The Simpsons. It's bizarre, and they're writing some very funny stuff.

We've been running a little behind schedule. But only by about 15 years or so.

Because good writing in a TV cartoon is so rare, I think the animation on The Simpsons is often overlooked.

I also found child's play - stuff that was not considered serious, but goofy - was the stuff I liked to do, so I still do it as an adult.

I don't know why I did it, I don't know why I enjoyed it, and I don't know why I will do it again.

I want it to go on, but I want us to go out on top.

Families are about love overcoming emotional torture.

Donuts. Is there anything they can't do?

Love is a snowmobile racing across the tundra and then suddenly it flips over, pinning you underneath. At night, the ice weasels come.

I've loved science fiction ever since I was a little kid, mainly from looking at the covers of science-fiction magazines and books, and I've read quite extensively as an adult.

Me fail english? Thats unpossible.

I draw a weekly comic strip called Life in Hell, which is syndicated in about 250 newspapers. That's what I did before The Simpsons, and what I plan to do for the rest of my life.

It's a funny show. The characters are surprisingly likable, given how ugly they are. We've got this huge cast of characters that we can move around. And over the last few seasons, we've explored some of the secondary characters' personal lives a bit more.

I love the idea that we put in jokes the kids don't get. And that later, when they grow up and read a few books and go to college and watch the show again, they can get it on a completely different level.

Here's to alcohol: the cause of, and answer to, all of life's problems.

It's just hard not to listen to TV: it's spent so much more time raising us than parents have.

I don't have to be careful, I've got a gun.

Most TV shows don't reward you for paying attention.

The writers led by Mike Scully are fantastic. And they're creating original stories that not only don't repeat what we've already done, they also don't repeat anything I've seen on television.

Eat my shorts!

Well, most grown-ups forget what it was like to be a kid. I vowed that I would never forget.

When the authorities warn you of the dangers of having sex, there is an important lesson to be learned. Do not have sex with the authorities.

Sometimes people get mad at The Simpsons' subversive story telling, but there's another message in there, which is a celebration of making wild, funny stories.

The thing that makes me happiest about Simpsons Illustrated are all the drawings that we get from readers. I wish we could print them all. They're really imaginative. They show a lot of hard work.

Everybody doesn't have to get every joke. People really appreciate not being condescended to.

God often gives nuts to toothless people.

Love is a perky elf dancing a merry little jig and then suddenly he turns on you with a miniature machine gun.

'The Simpsons' basically - and 'Futurama' - are really smart shows. They're kind of disguised as these goofy animated sitcoms, but the references within the shows, if you're paying attention, are pretty smart and pretty sophisticated.

'The Simpsons' from the very beginning was based on our memories of brash '60s sitcoms - you had a main title theme that was bombastic and grabbed your attention - and when you look at TV shows of the 1970s and '80s, things got very mild and toned down and... obsequious.

'The Simpsons' is about alienation and the ambivalence of living with a family who you love but who drive you completely crazy.

'The Simpsons' obviously is a huge success, and Fox has nothing to do with its success, with its creative success, and as a result they don't really like the show. They don't like 'The Simpsons' at Fox.

As astute followers of 'Life in Hell' will notice, Akbar and Jeff wear the same striped T-shirt as Charlie Brown. 'Peanuts' was very important to me.

Cartooning is for people who can't quite draw and can't quite write. You combine the two half-talents and come up with a career.

Charles Schultz is a really interesting case. He wrote that comic strip and drew it himself from beginning to end, and it's a work of genius. It's very simply drawn, but it has some really deep emotions that you don't expect in a silly-looking comic strip.

I basically drew my own family. My father's name is Homer. My mother's name is Margaret. I have a sister Lisa and another sister Maggie, so I drew all of them. I was going to name the main character Matt, but I didn't think it would go over well in a pitch meeting, so I changed the name to Bart.

I grew up completely overwhelmed by TV, and part of the reason why I have gone into television is as a way to justify to myself all those wasted hours of watching TV as a kid. I can now look back and say, 'Oh, that was research.'

I had been drawing my weekly comic strip, 'Life in Hell,' for about five years when I got a call from Jim Brooks, who was developing 'The Tracey Ullman Show' for the brand-new Fox network. He wanted me to come in and pitch an idea for doing little cartoons on that show.

I judge my life by how miserable it used to be. If I could pay my rent, I was deliriously happy. Now I'm deliriously happy all the time.