The key to sitcom success is miserable people. If you see a happy couple, it's just gone, like when Sam and Diane got together on Cheers.

Well, I was lucky enough to be involved in about 19 failures at an early age, so I'm realistic about the success I'm having and how quickly it can go away. What's important is to be smart about it.

I'm a sensitive guy. If you are a woman and you're in any kind of emotional duress and you write a song about it, I'll buy you album.

I've just found out there are pages on the internet dedicated to whether I'm gay or not.

I can tell if someone is talking to me because I'm on "Friends" or cause they just think I'm neat. You know I don't think I've ever spent more than five or ten minutes with somebody who was ogling me because they recognized me from the show.

The goal is to have to do the shot again because the camera guy shook a little bit as he was laughing. Without that happening, I'm not happy because there's nothing better for me than a world that everybody's just trying to make each other laugh.

I would like you all to give me a round of applause as I have not crashed my car in over 15 months.

I love the idea of "the one" but I actually believe that there isn't a Miss Right. There are 12,000 Miss Rights out there and it's all timing.

I got sober because I was worried I was going to die next year.

The key to sitcom success is miserable people. If you see a happy couple, it's just gone, like when Sam and Diane got together on Cheers.

Ninety percent of video game AI really is pretty damn bad. I think that's actually why it's so much fun to shoot things. Because the AI is so bad and the characters are so annoying.

There are two ways to go when you hit that crossroads in your life: There is the bad way, when you sort of give up, and then there is the really hard way, when you fight back. I went the hard way and came out of it okay. Now, I'm sitting here and doing great.

Chandler's the guy everybody thinks will do well with women, but he thinks too much and says the wrong thing.

I used to be a real prince charming if I went on a date with a girl. But then I'd get to where I was likely to have a stroke from the stress of keeping up my act. I've since learned the key to a good date is to pay attention on her.

As an actor, being on autopilot is the worst thing possible.

If there's a silence in a room I'll try to fill it as soon as humanly possible.

After I got my first laugh on stage, I was hooked.

Vicodin, I got addicted to that little pill. The reason I don't talk about it too much in the press is because it isn't funny, and I love to be funny in interviews. If you joke about that period in your life, it doesn't seem right.

'The Whole Nine Yards' I liked right away. It was kind of a dark comedy at first. And just the idea of being in a movie with Bruce Willis was pretty exciting.

A lot of people think that addiction is a choice. A lot of people think it's a matter of will. That has not been my experience. I don't find it to have anything to do with strength.

As for my personal life, I'd love to start a family of my own. I think I'd make a great dad, and I think shortly I would make a great husband.

I am fine with the fact that some of my hair is gray. If it was all gray overnight, that would be a scary thing.

I can tell if someone is talking to me because I'm on 'Friends' or cause they just think I'm neat. You know I don't think I've ever spent more than five or ten minutes with somebody who was ogling me because they recognized me from the show.

I certainly like the rumour that I was the father of Elizabeth Hurley's baby. It made me think I could impregnate women in a different way to everyone else. Elizabeth and I were never alone in a room together, so I must be a very powerful man indeed. Actually, I'm thinking of suing the baby!

I certainly wear my heart on my sleeve, and I think that comes out in the characters that I play. There's a yearning, or something, that comes out of me that people relate to.

I don't need to be reminded that I was on 'Friends.' I remember - some of it, anyway.

I have a huge interest in hockey because I grew up in Canada, where it's kind of the law that you love hockey.

I have a well-documented history of trouble with intimacy.

I learned a valuable lesson doing 'Mr. Sunshine,' which is that I didn't want to be in charge because it's too much. Being in charge and acting in every scene was just too difficult. It's like eating dinner in a moving golf cart every night.

I love the idea of 'the one' but I actually believe that there isn't a Miss Right. There are 12,000 Miss Rights out there and it's all timing.

I loved playing Chandler. I grew up playing that part.

I need a woman to have a quirky sense of humor. There's a bunch of jokes I use, and if she doesn't get them, she's probably not for me.

I never really thought of myself as a physical comedian. But when I was a kid, I used to, you know, pretend to trip over things to make girls laugh in school and stuff like that. So I kind of learned how to fall without hurting yourself.

I think if you look back at all those great comedies on television in the past, it's all lovable losers that gathered together - 'Taxi' and 'Cheers,' 'Seinfeld' and 'Friends.'

I think we need to educate our doctors about addiction.

I used to spend a lot of time just thinking about myself, thinking that the party started when I showed up.

I was a very good tennis player in Ottawa, Canada - nationally ranked when I was, like, 13. Then I moved to Los Angeles when I was 15, and everyone in L.A. just killed me. I was pretty great in Canada. Not so much in Los Angeles.

I went to a high school that didn't have many people in it. There were, like, 60 people in my senior class. There was a group of cool kids and a group of really dorky kids, and I was probably the coolest of the really dorky kids.

I would always be the kid that got in trouble in school, that's for sure, for joking around.

I'd say that on 'Friends' my character was the guy bouncing around the room. I'm no longer that guy, necessarily, in my life. I used to be. But I'm not now.

I'm just glad that the whole John Wayne persona of a man is sort of old school now, because I'd never be able to do that. If that was the going rate today, I wouldn't be working.

I've certainly had a lot of experiences in my life where I was much too self-centered.

My favorite actor was, is, Michael Keaton. Certainly growing up, in the movie 'Night Shift' he did something brand new that I hadn't seen before that we all steal from now. And then it was in 1987 he did the movie 'Clean and Sober' and 'Beetlejuice' in the same year, and that was when I said, 'Wow, that's what I want to do.'

My favorite six words in recovery are: trust God, clean house, and help others.

My feeling on therapy is it's a luxury, and if you're fortunate enough to get some smart people to talk to about life, then that's fortunate and you should go for it.

My sense of style is an old Polo shirt, jeans and, unfortunately for the longest time, white running shoes, which was not attractive. The one thing I've learned about clothes is to ask a girl.

Nine times out of 10, women don't want to fix a problem, they just want to be understood. I'll never get that.

That's like the greatest experiences of my life still, 'Friends,' so it's not something I want to get away from, but I do want to try and show something new.

The thing is, if I don't have sobriety, I don't have anything.