With any half-hour comedy, it kind of takes on its own life and finds itself.

The success of The Simpsons really opened doors. It showed that if you were working in animation you didn't necessarily have to be working in kids' television.

When you are in a room and your job is to write jokes 10 hours a day, your mind starts going to strange places.

You gotta keep the funny intact.

'American Dad' is, by its nature, much more political.

The only problem is time.

Chris Elliott could read the phonebook and he's funny.

The good thing about Broadway is that you don't have to worry about an airdate. It gets done when it gets done.

I wrote on a show called Johnny Bravo when I was at Hanna-Barbera.

Some of those more out-there jokes were written in the wee hours of the morning. Somehow, they remained funny the next day.

With any half-hour comedy, it kind of takes on its own life and finds itself.

'Family Guy' has this weird thing of attracting people. People either hate it or can't get enough of it. There's really no one in between.

'The Brady Bunch' asks nothing of you as a viewer. Sometimes is just what the doctor ordered.

At one point, I was hell-bent on being a Disney animator, and sort of got over that in college and wanted to do my own stuff. You know, towards the end of college I had actually planned to go to the Boston Conservatory of Music for musical theater.

Believe it or not, I have about the same success rate as anyone else. Sometimes you hit, sometimes you miss.

Denzel Washington has a great sense of humor. He did all those 'Nutty Professor' movies.

Every year, the Friday before the new Saturday-morning shows would premiere, the networks would do this big preview special, and I was always glued to the TV. As horrible as they were, they were entertaining at the time. There was a lot of showmanship from the networks based around the new lineup.

Everybody in my family had a real sick, twisted sense of humor. Most of the jokes we make in our house, we would just never even dream of making anywhere else. Just sick, horrible stuff. That wasn't anything new to college.

Evolution doesn't care whether you believe in it or not, no more than gravity does. I want to rekindle excitement over what we've achieved as a species with the space program. We can't afford to regress back to the days of superstition.

Fox is notorious for having a very thick skin about taking shots at themselves.

I always thought it would be funny to have the Parents Television Council write an episode of 'Family Guy' and give them full creative control. Then see how good the episode is. That's something we've actually discussed in the writers' room. We haven't proposed it yet, but if somebody from the PTC reads this, it might be worth discussing.

I can't believe I am hosting the Oscars. It's an honor everyone else said no.

I cannot tell good art from bad art. I have no eye for it.

I did a lot of theater when I was in high school and college. I also did stand-up in college, so it was always part of what I did.

I have a car that I like - an Aston Martin - for Sunday drives in the country.

I love the English. My God, they brought us 'Benny Hill,' 'Monty Python,' 'The Office,' Neville Chamberlain.

I spent my entire childhood in the same town, in Kent. I went to grade school there. There was a boarding school that my mother taught at, called - appropriately enough - Kent School, that I went to. Yeah, pretty much my entire childhood was spent in that town.

I still do a lot of drawing on a daily basis.

I think at times I read too much of my own press. I wish I was better at taking in how great my life is, but that's surprisingly elusive. I tend to be very hard on myself and insecure about failing no matter what happens.

I was a big Fred Flintstone fan.

I was a film major with a concentration in animation.

I was a huge 'Star Trek' fan. I loved the 'Twilight Zone' growing up. In the future, I hope to create some thoughtful, sci-fi drama.

I'll tell you what I think is not okay. Have you ever seen that show on MSNBC, 'Lockup?' It's a reality show that takes place inside a prison. Do the prisoners have to sign release forms? Or do they have to be on it whether they like it or not?

I'm one of the few people in Hollywood who actually had a good childhood.

I'm wide open to getting married, but actors are not easy people to date. You end up sharing that person with this other mistress that is their career. I very much like the traditional courtship method of making a date. That's what they do in normal places, but Hollywood's not normal.

If I were to do a musical, I think I would rather make a film musical.

If a song is funny and absurd, and it sounds great, it's just going to be that much funnier. And there's no better example of that than 'Monty Python.'

If something is shocking without being funny it's hard to justify.

If something sticks around long enough that it makes it to seasonal D.V.D. release, I'll watch it. That's how I watched 'The Sopranos'.

People do that on Facebook and it's the dumbest thing in the world. I don't care what your dinner looks like. Stop cluttering up the Internet with pictures of your dinner.

Science has become politicized, and that's an embarrassment.

The Simpsons are ugly-looking, and they should be. That's what works. That's one of the things that's funny.

The average person has eight different jobs over the course of their lifetime. You get a little antsy doing the same thing.

The quest for Tommy Lee Jones' laugh begins now.

The resistance to science is idiotic.

The success of 'The Simpsons' really opened doors. It showed that if you were working in animation you didn't necessarily have to be working in kids' television.

The trend today is vampires, zombies, angels, all the stuff that puts me right to sleep. It's too bad because it's so much less interesting than the diversity of stories you can tell with science.

The way Disney characters move, they're very kind of slow and fluid and flowing; one pose kind of eases into the next. If you look at a show like 'The Simpsons' and subsequently a show like 'Family Guy' - the characters will jerk from pose to pose a lot, a bit more snappy. Which sort of goes along with the writing tone of the show.

The worst thing to happen at the Oscars would be if nothing happened. You want something unscripted, something to riff on, something kinda out there.