Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

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It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.

Francis Crick

It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.

Francis Crick

We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s.

Francis Crick

The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.

Francis Crick

If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.

Francis Crick

If poly A is added to poly U, to form a double or triple helix, the combination is inactive.

Francis Crick

For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.

Francis Crick

If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.

Francis Crick

We've discovered the secret of life.

Francis Crick

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.

Francis Crick

It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.

Francis Crick

How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.

Francis Crick

It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.

Francis Crick

Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.

Francis Crick

Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

Francis Crick

Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.

Francis Crick

Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.

Francis Crick

It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

Francis Crick

This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.

Francis Crick

It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.

Francis Crick

The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.

Francis Crick

A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.

Francis Crick

The job of theorists especially in biology is to suggest new experiments. A good theory makes not only predictions but surprising predictions that then turn out to be true.

Francis Crick

The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.

Francis Crick

There is no executive order; there is no law that can require the American people to form a national community. This we must do as individuals and if we do it as individuals, there is no President of the United States who can veto that decision.

Barbara Jordan

You are not here merely to make a living. You are here in order to enable the world to live more amply, with greater vision, with a finer spirit of hope and achievement. You are here to enrich the world, and you impoverish yourself if you forget the errand.

Woodrow Wilson

I must stress here the point that I appreciate clarity, order, meaning, structure, rationality: they are necessary to whatever provisional stability we have, and they can be the agents of gradual and successful change.

A. R. Ammons

We need to begin an all-out diplomatic offensive on Darfur in order to prepare the way for a peacekeeping force that can ensure protection for the people of Darfur.

Kendrick Meek

Everything has to be pulling weight in a short story for it to be really of the first order.

Tobias Wolff

I don't like to hurt people, I really don't like it at all. But in order to get a red light at the intersection, you sometimes have to have an accident.

Jack Anderson

I think acting is about forgetting yourself in order to give the best of yourself. It's passing through you more than you're creating it. You're not the flower, but the vase which holds the flower.

Juliette Binoche

For someone who writes fiction, in order to activate the imagination and the unconscious, it's essential to be free.

Manuel Puig

It's a very hard and competitive business in which you have to fight every day in order to impose yourself.

Karolina Kurkova

I am co-counsel and as co-counsel I have the right to represent myself, speak for myself and conduct myself and my trial by myself in my best interests in order of due process.

Lynette Fromme

I wanted to make the violence beautiful in order to heighten our revulsion.

Edward Hall

An original artist is unable to copy. So he has only to copy in order to be original.

Jean Cocteau

Each day, and the living of it, has to be a conscious creation in which discipline and order are relieved with some play and pure foolishness.

May Sarton

Testimony is an integral part of the Black religious tradition. It is the occasion where the believer stands before the community of faith in order to give account of the hope that is in him or her.

James Hal Cone

I don't fear death because I don't fear anything I don't understand. When I start to think about it, I order a massage and it goes away.

Hedy Lamarr

Attempt the impossible in order to improve your work.

Bette Davis

I don't think you need a record deal to write songs. You don't need any other reason than you want to do it. It's a far cry from why some people do music today. They make it to order, which is pretty horrible.

Andy Taylor

I do to keep things sounding fresh. Sometimes just changing the running order of the show is a good idea.

Mick Taylor

Fascism is not in itself a new order of society. It is the future refusing to be born.

Aneurin Bevan

I ask every Communist individually to set an example, by deeds and without pretense, a real example worthy of a man and a Communist, in restoring order, starting normal life, in resuming work and production, and in laying the foundations of an ordered life.

Janos Kadar

And so, in case we have contingencies and things that we cannot accomplish within the duration of the space walk, we have a buffer, I mean, in order to be able to complete the... what we want to accomplish.

Umberto Guidoni

A man's moral conscience is the curse he had to accept from the gods in order to gain from them the right to dream.

William Faulkner

In order to win you must be prepared to lose sometime. And leave one or two cards showing.

Van Morrison

You need the words, you need the script, you need the material, you need the commitment, you need the passion, it's like we depend on writers, we depend on producers, directors depend on us and once things are in the divine order as they happen.

Nia Long