My goal was to develop into an independent research scientist studying clinical problems at the laboratory bench, but I felt that postgraduate residency training in internal medicine was necessary.

It is a remarkable honor to receive a Nobel Prize, because it not only recognizes discoveries, but also their usefulness to the advancement of fundamental science.

The Department of Cell Biology at Johns Hopkins was founded and directed by Tom Pollard, an engaging young scientist with remarkable energy and enthusiasm.

My brother Jim and I spent many wonderful summers working on dairy farms in Wisconsin owned by Mom's cousins, and as members of our local Boy Scout troop.

My goal was to develop into an independent research scientist studying clinical problems at the laboratory bench, but I felt that postgraduate residency training in internal medicine was necessary.

We always had lutefisk for Christmas dinner, after which Dad read from the Norwegian Bible.

In 1862, Abraham Lincoln signed the Homestead Act, a bill opening one half million square miles of territory in the western United States for settlement.

Following my junior year in high school, I went on a camping trip through Russia in a group led by Horst Momber, a young language teacher from Roosevelt.

Our lab had always refrained from keeping our studies secret.

The long, cold Minnesota winters instilled in me a fascination for exotic far off places; I aspired toward a career in tropical diseases and world health problems.

Johns Hopkins introduced me to two defining events in my life: commitment to biomedical research and meeting my future wife, Mary.

Dad was a chemistry professor at Saint Olaf College in Minnesota, then Oxford College in Minnesota, and a very active member of the American Chemical Society education committee, where he sat on the committee with Linus Pauling, who had authored a very phenomenally important textbook of chemistry.

Every cell in our body is primarily water. But the water doesn't just sit in the cell, it moves through it in a very organized way. The process occurs rapidly in tissues that have these aquaporins or water channels.

I grew up in Minnesota. Four generations of my father's people are buried there.

In science, one should use all available resources to solve difficult problems. One of our most powerful resources is the insight of our colleagues.

Mother had to support herself at age 18 because it was during the depression and when my grandfather lost the farm and there was no place for her; she worked as an assistant to a maid.

Natural selection is not an inflammatory phrase; evolution is.

Now a cholera epidemic was sweeping through Southeast Asia and south Asia in the early 1970s, so I started medical school and I joined a laboratory to work on this.

Now in the 21st century, the boundaries separating chemistry, physics, and medicine have become blurred, and as happened during the Renaissance, scientists are following their curiosities even when they run beyond the formal limits of their training.

Often times the public school teachers are ridiculed or they are made to feel inferior but this is really undeserved.

So, my advice to young scientists is, think critically about your work; probably don't blab unnecessarily.

Until 1985, when my lab found the protein they are made of, aquaporins hadn't yet been identified. There had been a controversy in biology for more than 100 years about how water moved through cells.

Water is commonly regarded as the 'solvent of life,' since our bodies are 70% water. All other vertebrates, invertebrates, microbes, and plants are also primarily water. The organization of water within biological compartments is fundamental to life, and the aquaporins serve as the plumbing systems for cells.

Well, all life forms are dependent upon water.

Well, my take was people of Minnesota, these are good people. They're in many ways more generous than other parts of the country. They're better educated than other parts of the country.

While the lab plays an enormous role, research is also influenced by inner peace of mind and one's family environment, depending on what stage of one's life and career a scientist is at.

Written in 1895, Alfred Nobel's will endowed prizes for scientific research in chemistry, physics, and medicine. At that time, these fields were narrowly defined, and researchers were often classically trained in only one discipline. In the late 19th century, knowledge of science was not a requisite for success in other walks of life.

My goal is, of course, for this show to do well, and I would love it if people liked it.

A goal without a plan is just a wish.

The best thanks we could offer those who went before and raised the Irish working class from their knees was to press forward with determination and enthusiasm towards the ultimate goal of their efforts, a Co-operative Commonwealth for Ireland.

The best people renounce all for one goal, the eternal fame of mortals; but most people stuff themselves like cattle.

If you take the creation of music and the creation of your own life values as your overall goal, then living becomes a musical process.

What had begun as a movement to free all black people from racist oppression became a movement with its primary goal the establishment of black male patriarchy.

Potentially he could be. He scored the goal four years ago in France against Argentina that was extraordinary.

To live for some future goal is shallow. It's the sides of the mountain that sustain life, not the top.

My back to the goal, physically fighting off defenders, trying to bang my goals in, every week I have to do the business for this club. That's the life of a striker.

And the goal really is to make the audience laugh, to bring them some joy.

My goal was always to be recognized as a good actor but no one was interested in that, simply because society just wants to warm towards your appearance. This is the great blemish of society.

The Bush administration also was not straightforward about the intelligence it had, releasing tenuous information that fit its goal of attacking Iraq. I feel deceived.

Composers, like authors, have a lot in common. Our main goal is to connect with the listener emotionally.

If you consider that a typical Central American consumer earns only a small fraction of an average American worker's wages, it becomes clear that CAFTA's true goal is not to the increase U.S. exports.

But if you believe in Christ and that your main goal with your life is supposed to be to honor Him and do His will, then you don't have as much pressure as someone who bases all their happiness on whether they're a movie star.

Music is my main goal, but I'm not going to rush a record out. There are so many actors who have come out with albums these days. I don't want to do it because it's the thing to do. I want to wait until the time is right.

In philosophy, it is not the attainment of the goal that matters, it is the things that are met along the way.

I'd wanted to be an actress my whole life, that was my goal, that was all I cared about.

A joke is not a thing but a process, a trick you play on the listener's mind. You start him off toward a plausible goal, and then by a sudden twist you land him nowhere at all or just where he didn't expect to go.

You may be a redneck if... your lifetime goal is to own a fireworks stand.

A politician's goal is always to manipulate public debate. I think there are some politicians with higher goals. But all of them get corrupted by power.

Research and development needs permanent tax credits to build the technology that spurs our growth. But no government programs alone can get America's students to study more science and math; parents must push and help their children to meet this goal.