In 1995, I founded The Molecular Sciences Institute with a gift from the Philip Morris Company where I hoped that we could create an environment where young people could pursue science in an atmosphere of harmonious purpose and high intellectual challenge.

He told me that Francis Crick and Jim Watson had solved the structure of DNA, so we decided to go across to Cambridge to see it. This was in April of 1953.

During this period, I became interested in how the new techniques of cloning and sequencing DNA could influence the study of genetics and I was an early and active proponent of the Human Genome Sequencing Project.

There was still food rationing in England and life was difficult all through my 2 year stay in Oxford.

The modern computer hovers between the obsolescent and the nonexistent.

I completed the first three years of primary school in one year and was admitted to the local school the age of six directly into the fourth year, some two years younger than all my contemporaries.

I set up a laboratory in the Department of Physiology in the Medical School in South Africa and begin to try to find a bacteriophage system which we might use to solve the genetic code.

In 1995, I founded The Molecular Sciences Institute with a gift from the Philip Morris Company where I hoped that we could create an environment where young people could pursue science in an atmosphere of harmonious purpose and high intellectual challenge.

In my second year, after moving to the Medical School, I began the courses of Anatomy and Physiology. I had begun to see that I was interested in cells and their functions.

I also became interested in chemistry and gradually accumulated enough test tubes and other glassware to do chemical experiments, using small quantities of chemicals purchased from a pharmacy supply house.

So that's when I saw the DNA model for the first time, in the Cavendish, and that's when I saw that this was it. And in a flash you just knew that this was very fundamental.

The moment I saw the model and heard about the complementing base pairs I realized that it was the key to understanding all the problems in biology we had found intractable - it was the birth of molecular biology.

Living most of the time in a world created mostly in one's head, does not make for an easy passage in the real world.

Many have gone on to do important scientific work but all remember those wonderful times when we and our science were young and our excitement in meeting new challenges knew no bounds.

I lived at home and I cycled every morning to the railway station to travel by train to Johannesburg followed by a walk to the University, carrying sandwiches for my lunch and returning in the evening the same way.

I went in with Jack and Leslie, into this room that was lined with brick, and there on the side I can remember very clearly was this small model with plates for the bases - the original model with everything screwed together.

Roosevelt's magic lay in one facet of his personality: He knew how to take the risk. No other man in public life I knew could so readily take the challenge of the new.

To do the Ozzfest again would be great. I'd like to finish with a final Sabbath album. You always feel that it is still a challenge.

People are not perfect... very often the relationships that are strongest are those where people have worked through big crises, but they've had to work through them. So the challenge to us is to work through that.

Every single book is a challenge.

Critics are sentinels in the grand army of letters, stationed at the corners of newspapers and reviews, to challenge every new author.

The lopsided attitudes of college professors pose a serious challenge to learning because students are so susceptible to becoming lopsided sheep.

I really enjoy comedy. It's a real challenge.

I had a hard time with that hockey. I hadn't grown up skating, so that was my biggest challenge. We worked on it and worked on it. But then when we first shot it, it was so hard for me.

The challenge is to practice politics as the art of making what appears to be impossible, possible.

Change can either challenge or threaten us. Your beliefs pave your way to success or block you.

My greatest challenge has been to change the mindset of people. Mindsets play strange tricks on us. We see things the way our minds have instructed our eyes to see.

I'd say that it's important for music to be there that gives you a challenge, that rearranges things in your head.

I like good stories. Quality products and character are what's important. Even if the script isn't that strong, if I challenge myself with a great character, I'll go for it.

I tend to arrive in the rehearsal process with very strongly developed ideas about what I want to do. But I don't like those ideas to be things that are not subject to change, or subject to development, or subject to challenge.

I'm not looking to set a standard... but, I believe I have offered a challenge to others with my work.

If you live a life of make-believe, your life isn't worth anything until you do something that does challenge your reality. And to me, sailing the open ocean is a real challenge, because it's life or death.

And, I'd never done Tennessee Williams, and I had done Broadway musicals, so it was a challenge.

When you remove the risk, you remove the challenge. When you remove the challenge, you wither on the vine.

After Land I wanted to continue exploring the theme but I needed a new challenge so turned to colour. I explored Bradford and produced a series of urban landscapes that I liked, but because Land had made such an impact on the general public my colour work wasn't reviewed.

The worlds I paint leave a lot to engage the imagination by hinting at what lies beyond the four edges of the painting. I think getting beyond the four edges of an opportunity or challenge is one of the basic skills you need in business.

For me, it's a bigger challenge, it's much harder to do and much more rewarding to do well, then just to think up stuff of your own, hit or miss, because you've got to see to it that you don't torpedo any of his punch lines.

This same habitual blindness to spiritual, substantive dimensions of every significant challenge continues to handicap Hollywood.

Every artist has to grow, and has to challenge themselves with a new form of expression.

The next challenge for Christianity is to remind Europeans that we are called to seek the truth.

Give yourself an even greater challenge than the one you are trying to master and you will develop the powers necessary to overcome the original difficulty.

The biggest challenge has been simulating a tornado with wind machines and dirt and debris. Right when you walk on the set, you feel the energy of a tornado. But the hardest thing is trying to get dialogue out in all of that.

I look at raising funds for The Perlman Music Program as a challenge and as a way to provide opportunities for people who care about the future of classical music.

My father instilled in me the attitude of prevailing. If there's a challenge, go for it. If there's a wall to break down, break it down.

The challenge in working in politics, particularly if you're working for a political party, is that everyone's a messenger.

People should not be imprisoned without having the ability to challenge the legality of that imprisonment.

Every Teen Challenge ministry is responsible for raising its own finances, but we assist these works with finances, prayer and counseling, especially overseas in areas such as Siberia, Africa, South America.

It took me about 12 years to reach my million-word mark. The challenge now is to continue to challenge myself.

Roddick can challenge him as well if he serves big consistently for the entire match. If he does that, then he is tough to break even for a guy like Federer.