I have always loathed working out.

People don't know this, but early in your career, you don't just glide on to The Tonight Show.

Really it was the first time in my life that I recognised that acting is, I'm just going to say it, I am an artist, I have to do this, I have to do this.

I'm not a huge fan of my work.

I have always loathed working out.

At one point, I had 14 pairs of golf shoes.

Sometimes, I feel that Manhattan in particular has gotten really tame and gentrified or something.

I don't think, there's no possible way for me, anyway, to play a character that I haven't found some sort of sublime compassion for and I related to Deborah on a way that almost, initially, almost in a way maybe someone in the audience might.

I dress up for awards, but only if somebody else is going to pay for the clothes. And shop for them, too!

Well, I think again, the worst part of it was just leading up to it, before we got on set, at least for me... dreading this idea that I was just going to suck and I really had strong feelings about that. I just didn't want to be that weak link.

Shopping turns me off.

Yes, I guess I am bi-coastal.

Acting doesn't feel good. It's not comfortable to feel all this stuff, it's not.

But I've never looked at myself as being particularly funny.

The one thing I think you must do is, as painful as it is as a parent, is listen.

I've been in a gym probably nine days of my life.

And I thought, you know, I have to say that maybe the whacked out mother is my new favorite role, but I don't want to just do it and become Nurse Ratchett.

I'm not quite ready for a no makeup movie.

I just mean it's very difficult for me to watch my work, in some ways, because I am critical of what I didn't get across or I thought I was making one point.

Well what I will tell you is for this movie, I got into probably the best shape of my life.

But I can tell you that the New York that I see now is not the New York that we grew up in. It's not 1973.

First of all, returning from motherhood, I was looking for something lighter, and I wasn't as much attracted to Kate as I was to the relationship between the two people.

If I swim in the ocean, I have a shark thought. Not a bad one, but just a little one.

I was desperate to go back to New York and when 9/11 happened, I feared moving to the bulls-eye and that was very hard because I have a lot of family there and I really had to question what I didn't like about this community.

It was just this interesting, my first, the first time you hear your child in any way criticise you. It's the worst review of your life and it's really relieving to find out that they don't know what they're saying.

I live by a hill. I began walking it and then I began jogging it and then I began sprinting it.

Jim Brooks is a very powerful director and it was a lot of intense work.

I don't mean to be presumptuous that men don't feel this, I don't mean this, but I found that when my child was born, my first child, it felt like my heart broke.

Well, I don't find glamour and clothing relevant.

It's kind of fun to be sexy.

I was one of the most brilliant liars as a child.

The concept of randomness and coincidence will be obsolete when people can finally define a formulation of patterned interaction between all things within the universe.

I love musicals; I love the ballet, opera, the circus. It's all performance to me.

22 million new jobs under President Clinton. 3 million lost under Bush.

Paul Rudd is too perfect. He's super talented, super nice and super calm. I just think he's a robot.

You know what isn't class warfare? Progressive taxation, as in, say, expecting billionaires to pay at least as much in taxes as their secretaries. Ideally, in fact, they should pay more.

All I really want is a three-room house. The home I have designed at my new farm in Bedford, New York, is a three-room house: bedroom on top, living room in the middle, and kitchen on the ground.

Richard III is not likeable. Macbeth is not likeable. Hamlet is not likeable. And yet you can't take your eyes off them. I'm far more interested in that than I am in any sort of likeability.

When you become a mom you just learn how to function sleep deprived and you do get used to it. I came back to work when Finley was three months old and the first few months were rough. Then somehow you learn to exist on no sleep and now when he does upon occasion sleep through the night, which is like a full six hours, you're pretty sure he's suffocating. So you don't sleep anyway.

He who wants to do good, knocks at the gate; he who loves finds the gates open.

Perhaps one has to be very old before one learns to be amused rather than shocked.

One must beware of ministers who can do nothing without money, and those who want to do everything with money.

I was first exposed to the idea of macro-molecular sequences while I was a postdoctoral fellow with Jack Strominger at Harvard. During that time, I briefly visited Fred Sanger's laboratory in Cambridge, England, to learn the methodology of RNA fingerprinting and sequencing.

Of the four wars in my lifetime, none came about because the U.S. was too strong.

I'd never devote a whole record to heartbreak.

I work 338 days a year, 16 hours a day.

I was raised in a spirit of the importance of service to your fellow man. My mom is a senator back home in South Africa. My father is a very caring and generous individual.

The largest party in America, by the way, is neither the Democrats nor the Republicans. It's the party of non-voters.

That foreign trade should be fair rather than free.