Startups are unique animals. We take them pretty much for granted out here now, but they are still endeavors that require very different skills from the ones needed in established companies.

Anyone can sail with the wind to his back. Startups usually sail into a stiff wind, leaking like a sieve, in high seas, without food or water.

In the world of startups, angels invest in seed or early-stage deals, and with their money they lend a bit of advice. They pay for the privilege of helping the company.

Good entrepreneurs are passionate visionaries, usually with one or more exceptional talents, but rarely have they actually built a company from scratch.

It's not clear that being the first-mover will provide the rash of Internet startups a sustainable competitive advantage. Ultimately being right, or better positioned, may be more important than being first.

Deferred Life Plan: Step one: Do what you have to do. Then, eventually — Step two: Do what you want to do

Most business ideas do not find funding. Even the majority of those that are funded—that is, vetted by very smart people who think enough of the ideas to invest in them — ultimately fail.

It's the romance, not the finance that makes business worth pursuing.

Entrepreneurs, in my experience, don't like to be told they're wrong.

The business model can and should change over time, as the world changes.

Business conditions are forever changing. You need to reconsider your strategies and business models constantly and adjust them where necessary.

Business is about nothing if not people.

Silicon Valley veterans share a tacit understanding that what a startup needs isn't one CEO, but three —each at successive stages of the startup's development.

If you turn a visionary startup into an operating company too early, you throw out its birthright. It will never be as big, or as influential as it might otherwise be. It will be much harder, perhaps impossible, to expand the vision later, when performance is being measured, because then there's too much at stake.

Business failures are unfortunate but necessary steps in the search for those few huge successes.

If you're brilliant, 15 to 20 percent of the risk is removed. If you work twenty-four hours a day, another 15 to 20 percent of the risk is removed. The remaining 60 to 70 percent of business risk will be completely out of your control..

Work hard, work passionately, but apply your most precious asset — time — to what is most meaningful to you.

Time is the only resource that matters.

Only allow yourself to think negative thoughts and/or complain about anything for three minutes, three times a day.

The anorexic body is held in the grip of will alone; its meaning is far from stable. What it says - 'Notice me, feed me, mother me' - is not what it means, for such attentions constitute an agonising test of that will, and also threaten to return the body to the dreaded 'normality' it has been such ecstasy to escape.

The reason we shot it was that the script was geared to Las Vegas and it was something commercial that we wanted to have in the can in case Butterfly was a success and we needed a follow-up.

I cannot think of anything more difficult than to say something which would be worthy of this impressive and, for me, memorable occasion, and of the ideals and purposes which inspired the Nobel Peace Award.

They know they're going to look beautiful, and I don't think women should look like costumes. They shouldn't look like fashion victims.

But, we didn't have all the media that we do today.

You can go other places, all right, you can live on the other side of the world, but you can't ever leave home.

I've never looked at a suburban building as being a minor building and an urban building as being a major building.

Ensuring Americans have access to adequate medical care should be a priority for all of us.

You realise the responsibility of carrying a film on your shoulders when people are investing money in you and they recognise the hard work you have to put in.

To be really great in little things to be truly noble and heroic in the insipid details of everyday life is a virtue so rare as to be worthy of canonization.

Be happy in your own skin.

Death is delightful. Death is dawn, The waking from a weary night Of fevers unto truth and light.

The best book on programming for the layman is 'Alice in Wonderland'; but that's because it's the best book on anything for the layman.

It's hard with ballet because your aesthetic really is important. It's different from acting and from film. Nobody wants to watch somebody who is sickly thin. And it's interesting because I have danced with people who are ill, have eating disorders, and a light goes off within them.

The Sabbath is not a day to feast our bodies, but to feed our souls.

I'm a big fan of 'Woody Allen' movies, so I like all the actresses in his movies like 'Diane Keaton' and Mia Farrow.

Our enemies, like the Grecian hero, have one vulnerable point. You have not touched it yet. What should have been their element of weakness has been suffered to remain an element of strength.

Someone once told me I'm a sore winner, and they're right. I rarely take more than a moment to enjoy a success before I'm moving on and looking for the next challenge.

A certain traveler who knew many continents was asked what he found most remarkable of all. He replied: the ubiquity of sparrows.

Good ideas are free - or at least they should be.

In the past it seemed like I was making fun of rap a little bit. But it was more me making fun of myself, since I'm not technically a rapper, whatever that means.

Over the years I've tried to be clear about the things that are important in life, the things that matter, and I've tried to pursue them, and, I've had a certain sense of 'stickability,' hanging in there, and I suppose that's me.

The Global Fund is a central player in the progress being achieved on HIV, TB and malaria. It channels resources to help countries fight these diseases. I believe in its impact because I have seen it firsthand.