Casi todos los fármacos son ácidos o bases débiles que están en solución, en su forma ionizada y no ionizada (liposolubles)

La administración idónea de un medicamento consigue que el fármaco acceda al lugar del organismo donde es activo.

Vía Parenteral: Administrar el fármaco por inyección a un compartimiento del cuerpo o cavidad evitando el efecto protector de la piel y las mucosas. Las formas farmacéuticas son soluciones, suspensiones, emulsiones Los preparados deben ser estériles, apirógenos e isotónicos

Factores que influyen en absorción Superficie de absorcion Espesor de la membrana Tamaño o peso molecular Grado de division Forma cristalina o amorfa Grado de ionizacion Liposolubilidad

Luego de la absorción el fármaco se distribuye en los líquidos intersticial e intracelular. Depende del gasto cardíaco, la corriente sanguínea regional, permeabilidad capilar, y el volumen hístico.

Órganos que tienen mayor irrigación reciben la mayor parte del medicamento: hígado, riñones, encéfalo En la segunda distribución llega músculos, vísceras, piel y grasa

I discovered in college that country music could be fun adding some swing to it.

Learn from the mistakes of others. You can't live long enough to make them all yourselves!

I have learned how to plant coastal hay, fertilize and bale it.

Look, I am not worried about Washington cutting too much spending too fast. I mean, the kinds of spending cuts we're talking about just right now are $100 billion out of a $3.7 trillion budget.

The Bay of Pigs was an operation the United States endorsed. That was a preventive operation. We were afraid that Castro was going to subvert the hemisphere.

I've been blessed with a lot of great things in my life, and one of them was work ethic. And with work ethic, you can make anything happen.

Skating is an amazing form of self expression. It's like my soul at play.

Some countries that I go to are still trying to deny that it's happening. In India, 2.1 million people are living with HIV AIDS. India manufactures most of the drugs that are used to cure HIV around the world, which is an amazing, amazing fact that most people don't know.

I remember doing a comedy show with Jim Carrey once, and he was out there with his foot behind his neck and rubbing his face with it.

I don't want to be unapproachable.

It's a phenomenon that we don't really understand.

I am not a fan of referencing your own work when it's in a different universe than what you're doing. That, to me, is a wink at the audience, and winking isn't actually cool when you're not, like, 10.

My parents are desperate, they keep saying: 'Please stop doing these angsty roles; make it easier for us.' So, yeah, I'd love to do some comedy.

Being on stage is the best part of my career. I just say whatever comes into my head. It's the only time I feel grown-up and in control of things.

God will have a humble people. Either we can choose to be humble, or we can be compelled to be humble.

If I spent all my time criticising myself, I wouldn't be able to function. There are actors who theorise till the cows come home. I haven't the patience for them. It's maybe shallow, but that's why I'll never be part of the acting set.

I miss my hair, but I feel like going out there with some fake braids wouldn't be right. I want to be the most genuine performer I can be.

These are the same people who believe, in some cases, the federal government should not play any role in providing health care to our people or protecting the environment.

Comic art is just different. It's art on its own terms.

Developing countries often have hypertrophied bureaucracies, requiring businesses to deal with enormous amounts of red tape.

My mother had a master's degree and had been a schoolteacher before she started having kids at 30. But my father's family were landowners, farmer-merchants. Moneymaking was extremely important, like one of those semi-rapacious families in Lillian Hellman, where they know the price of everything and the value of nothing.

We talked about the Internet and Wikipedia and how facts and history are being collectively created online.

I have been a fan of Dexter since the pilot. Once I got the audition I just squealed, and you would have thought I just won 45 million dollars.

Jack Kennedy always said to me, Hedy, get involved. That's the secret of life. Try everything. Join everything. Meet everybody.