Órganos que tienen mayor irrigación reciben la mayor parte del medicamento: hígado, riñones, encéfalo En la segunda distribución llega músculos, vísceras, piel y grasa

La administración idónea de un medicamento consigue que el fármaco acceda al lugar del organismo donde es activo.

Vía Parenteral: Administrar el fármaco por inyección a un compartimiento del cuerpo o cavidad evitando el efecto protector de la piel y las mucosas. Las formas farmacéuticas son soluciones, suspensiones, emulsiones Los preparados deben ser estériles, apirógenos e isotónicos

Factores que influyen en absorción Superficie de absorcion Espesor de la membrana Tamaño o peso molecular Grado de division Forma cristalina o amorfa Grado de ionizacion Liposolubilidad

Casi todos los fármacos son ácidos o bases débiles que están en solución, en su forma ionizada y no ionizada (liposolubles)

Luego de la absorción el fármaco se distribuye en los líquidos intersticial e intracelular. Depende del gasto cardíaco, la corriente sanguínea regional, permeabilidad capilar, y el volumen hístico.

I have a lovely light blue Kate Spade wallet. It has pockets for many credit cards, business cards, health insurance cards, and a Burke Williams card for when I want to go to the spa!

Politics was sort of a way of life in our family.

I feel like the better version of myself is on paper... I'd rather have people know me on paper.

Success or failure depends more upon attitude than upon capacity successful men act as though they have accomplished or are enjoying something. Soon it becomes a reality. Act, look, feel successful, conduct yourself accordingly, and you will be amazed at the positive results.

I've always said that theater was where I began, so everything I do now has a bit of my theater background in it. It was my training.

Mummy always wanted the five children, and she knew she couldn't look after them all because she was this absolutely glorious woman who loved going to parties and going to the races, and she just didn't have time.

Affirmative action is an effort to include every aspect of society in the decision making.

You have to want to be married to someone. You have to feel that reciprocated. Marriage for marriage's sake doesn't make any sense to me, and I found someone with whom I could put my money where my mouth is, I guess.

In the light of calm and steady self awareness, inner energies wake up and work miracles without any effort on your part.

One eye sees, the other feels.

I think our relationship with Epic had run its natural course, and it happened to coincide with the fulfillment of our contract. We decided not to resign with them.

My mother was a lupus patient. I was a child with the lupus gene.

Bureaucracy is the art of making the possible impossible.

Politics is the womb in which war develops.

Power does not corrupt. Fear corrupts perhaps the fear of a loss of power.

One day you will do things for me that you hate. That is what it means to be family.

Don't worry about what others think about you; worry about what they think of themselves when they're with you.

In fact, allowing immigrants to have licenses actually improves homeland security by allowing our government to track who is in our borders.

I don't have to ask anyone's permission to do anything. It's nice not have to get decisions out of three, sometimes four people, which can be like pulling teeth. So the amount of control that I have over what I'm doing is better for me as a solo artist.

Operas elucidate, in a way sometimes absent in other theatrical productions, the very human fact that in every hero, there is a thread of duplicity. In every villain, there is another side to consider: We don't have to like him or her, but we are compelled to think about motivation.

Many things shall change in Cuba, but they shall change because of our efforts and despite the United States. Perhaps that empire shall crumble first.

I just have to move forward and keep working on my game and getting better.

That was one of the reasons I became a writer - I never really had that many friends. I would read a lot, and listen to music. And that was my life.

The curious paradox is that when I accept myself just as I am then I can change.