Órganos que tienen mayor irrigación reciben la mayor parte del medicamento: hígado, riñones, encéfalo En la segunda distribución llega músculos, vísceras, piel y grasa

La administración idónea de un medicamento consigue que el fármaco acceda al lugar del organismo donde es activo.

Vía Parenteral: Administrar el fármaco por inyección a un compartimiento del cuerpo o cavidad evitando el efecto protector de la piel y las mucosas. Las formas farmacéuticas son soluciones, suspensiones, emulsiones Los preparados deben ser estériles, apirógenos e isotónicos

Factores que influyen en absorción Superficie de absorcion Espesor de la membrana Tamaño o peso molecular Grado de division Forma cristalina o amorfa Grado de ionizacion Liposolubilidad

Casi todos los fármacos son ácidos o bases débiles que están en solución, en su forma ionizada y no ionizada (liposolubles)

Luego de la absorción el fármaco se distribuye en los líquidos intersticial e intracelular. Depende del gasto cardíaco, la corriente sanguínea regional, permeabilidad capilar, y el volumen hístico.

When a movie is about to come out on its initial debut, there are a lot of people involved - the financiers, the studio and the producers and also, many times, the foreign distributors. So it is a time of tremendous pressure and uncertainty.

I like chicken a lot because chicken is generous - that is to say, it's obedient. It will do whatever you tell it to do.

I'm used to sort of improvising a lot when I do my comedies.

You can't really achieve anything in three years.

When you hear 'experience,' that's all about resume. And Obama didn't have the resume. But we knew, long before that, 'steady in a crisis' was much more important than 'experience.' When you watched the presidential campaign, you saw that Obama was the one who happened to be steady... He demonstrated aspects of his character people were hungry for.

I deserve attention not because of any talent, but just because of who I am.

These $40 burgers with foie gras and truffles and all of that flies in the face of one of the most proletarian foods around. It's overpriced, overdone and just not worth it.

After 2000 or so, I started to realize I wanted to be doing something else. I didn't want to be in front of a camera. I was frustrated. I didn't think I would stop acting, but I didn't want to be seen.

My sister and I both benefited hugely from the great security that our parents had given us, and then we went off and squandered it all rushing around in showbiz.

To summarize, the particular song a male sings, and the behavioral responses of females to song and morphological signals, are not genetically inherited in a fixed manner but are determined by learning early in life.

It's time for some common sense from federal agencies.

Some people think that going on a caravan holiday is a slightly more upscale version of camping. Let me assure you, it is much better than that. You know that you will have your creature comforts wherever you are. I never have to pack light, and I can put the kettle on in any location.

I guess I've always wanted to push the boundaries as an actor.

I absolutely believe in the power of tithing and giving back. My own experience about all the blessings I've had in my life is that the more I give away, the more that comes back. That is the way life works, and that is the way energy works.

People evolve and it's important to not stop evolving just because you've reached 'adulthood.'

Shows don't reunite because television doesn't work that way. There's no profit model and people go off to do other work.

Kennedy did not have to run the risk of having his ideas and his words shortened and adulterated by a correspondent. This was the television era, not only in campaigning, but in holding the presidency.

I don't think I'm like any of the characters I've played - they're all really far from who I am.

I'm merely trying to be something akin to a nice, kind, good actress.

Ever since I came to Congress in 1992, there are those who have been trying to silence my voice. I've been told to "sit down and shut up" over and over again. Well, I won't sit down and I won't shut up until the full and unvarnished truth is placed before the American people.

The millionaires and billionaires who chose to invest in Australia are actually those who most help the poor and our young. This secret needs to be spread widely.

I don't like guys who overdress. And I don't like guys who try too hard.

I always come to conclusions very fast. Well, that is one way of thinking, and the other way would be that I lack the necessary perseverance to stick to one thing that really fits me. I don't know if it's a good thing or bad thing.

The Olympic Games are a national cause, and a national cause calls for a nationwide attitude.