Luego de la absorción el fármaco se distribuye en los líquidos intersticial e intracelular. Depende del gasto cardíaco, la corriente sanguínea regional, permeabilidad capilar, y el volumen hístico.

La administración idónea de un medicamento consigue que el fármaco acceda al lugar del organismo donde es activo.

Vía Parenteral: Administrar el fármaco por inyección a un compartimiento del cuerpo o cavidad evitando el efecto protector de la piel y las mucosas. Las formas farmacéuticas son soluciones, suspensiones, emulsiones Los preparados deben ser estériles, apirógenos e isotónicos

Factores que influyen en absorción Superficie de absorcion Espesor de la membrana Tamaño o peso molecular Grado de division Forma cristalina o amorfa Grado de ionizacion Liposolubilidad

Casi todos los fármacos son ácidos o bases débiles que están en solución, en su forma ionizada y no ionizada (liposolubles)

Órganos que tienen mayor irrigación reciben la mayor parte del medicamento: hígado, riñones, encéfalo En la segunda distribución llega músculos, vísceras, piel y grasa

So many of the kids on television have really nice clothes, perfect skin and hair.

The truth of why I used to listen to Arrested Development on my Walkman was because if I didn't, it would take me 20 minutes to walk to school. If I did, it took me 15. That's the reason I loved it. I just had more of a kick in my step, more of a bounce, so I'd walk quicker.

I am never interested in the individual, but in the human species and its environment.

If I were a man with gills, I would be a fish!

Every picture tells a story.

I record all of my music with authentic instruments in a studio before we start editing, doing many, many versions. The music shapes the film as we edit so it has an organic relationship to the content.

It's fun to see how other artists adapt my work.

Life is a balance of fear and overcoming it.

Social-enterprise employees earn wages and pay taxes, reducing their recidivism rates and dependence on government assistance. They also receive crucial on-the-job training, job-readiness skills, literacy instruction and, if necessary, the counseling and mental-health services they need to move into the mainstream workforce.

My mother Diana was a true-blue aristocrat, descended from William the Conqueror and listed in 'Burke's Peerage.' My father David, from a poor Scottish family, was a doctor.

A memorable heart is the easiest way to immortality.

People love their comic books.

Bowling is not a sport because you have to rent the shoes.

You cannot do harm to someone because someone has done harm to you. You will pay just like they will.

You fight the most with your brother. The first fight you're going to get into is with your brother. The first fight you lose is going to be with your brother. But nobody else better try to fight your brother. Only you can fight your brother without it being a problem.

My mother is my root my foundation. She planted the seed that I base my life on and that is the belief that the ability to achieve starts in your mind.

I've accentuated the look over the years. As a comic, you try something and if it works you go with it and grind it to death.

Barack Obama is the worst President in history.

When you're recording in the midst of touring, you get a different sense about you. Things are more rocking, darker, heavier and louder. You're thinking about the audience that you're seeing every night.

Heartbreak is hard, but you find more and more things to be grateful for every day.

I've been criticised for writing in too complex a manner for younger people.

It's a cruel season that makes you get ready for bed while it's light out.

I am pretty sure that all young human beings have, at one time or another in their growing-up, been actors. They have used their imaginations to carry them away from painful or confusing situations... have imagined themselves to be more powerful or beautiful or brave or loving than they are.

The cosmetics industry has much to answer for. Its a multi million pound confidence trick based on giving women endless hope courtesy of overpriced little pots.