La administración idónea de un medicamento consigue que el fármaco acceda al lugar del organismo donde es activo.

Vía Parenteral: Administrar el fármaco por inyección a un compartimiento del cuerpo o cavidad evitando el efecto protector de la piel y las mucosas. Las formas farmacéuticas son soluciones, suspensiones, emulsiones Los preparados deben ser estériles, apirógenos e isotónicos

Factores que influyen en absorción Superficie de absorcion Espesor de la membrana Tamaño o peso molecular Grado de division Forma cristalina o amorfa Grado de ionizacion Liposolubilidad

Casi todos los fármacos son ácidos o bases débiles que están en solución, en su forma ionizada y no ionizada (liposolubles)

Luego de la absorción el fármaco se distribuye en los líquidos intersticial e intracelular. Depende del gasto cardíaco, la corriente sanguínea regional, permeabilidad capilar, y el volumen hístico.

Órganos que tienen mayor irrigación reciben la mayor parte del medicamento: hígado, riñones, encéfalo En la segunda distribución llega músculos, vísceras, piel y grasa

Im fat but Im thin inside... theres a thin man inside every fat man.

I'll sit around and play my guitar; that's how I write tunes.

Flops are always disappointing, but 'High Fidelity' was devastating. Not that I thought it was going to make me a big star, but I did think it was going to run longer than a week and a half.

God put us here to prepare this place for the next generation. That's our job. Raising children and helping the community, that's preparing for the next generation.

You watch a hockey game, and the hand-eye coordination and the speed is really miraculous; how those guys track the puck alone, just following it with their eyes.

I can promote until I am blue in the face, but ultimately nobody knows what makes a hit.

I don't believe there's two sides to every story. It's black and white. There's right and wrong.

In Ireland we have a very old saying, When you can see the mountains it's going to rain and when you can't see the mountains it's raining.

I've always loved men.

The expectations are that when this investigation is completed, Fitzgerald will make the appropriate decision, which is not to charge Karl with any criminal offenses.

It all goes back to 'Wow, I never knew this about Marco Polo.' This is an incredible story and an incredible character, and such a rich world of Mongolian and Chinese culture.

Credit is a system whereby a person who cant pay gets another person who cant pay to guarantee that he can pay.

We've done all the work that HRC wanted on the twin and the project has been completed. We were consistently up there with the top guys and that is what HRC wanted to prove.

Alan Cumming was such a fun guy to watch. I remember he has a song in the first 'Spy Kids' movie, and when Danny Elfman came to set, they were working on the song.

I will say that walking down the street, getting on the subway, taking the elevator, if there's one or two people and they say, 'Great job, Mayor,' that is a real turn-on. I mean, anybody that wouldn't find that satisfying, rewarding, exciting, thrilling - I think they should see the doctor.

I confront the European elite's self-image as tolerant 'while under their noses women are living like slaves.

My heroes were always Looney Toons, Robin Williams, the Three Stooges. I think everything I do is kinda funny. I think I'm sort of ridiculous.

The better one is morally the less aware they are of their virtue.

In my neighborhood... they view the police as someone who comes to take their loved ones away.

Circumstances cause us to act the way we do. We should always bear this in mind before judging the actions of others. I realized this from the start during World War II.

I think literary theory has not been terribly good for English studies in a while. It's not that theory isn't interesting, but it isn't about books, or the idiosyncrasies and complexities of putting language together.

Nearly every man who develops an idea works at it up to the point where it looks impossible, and then gets discouraged. that's not the place to become discouraged.

A lot of the films I like are more than fantasies - they're movies fascinated by the technology of space exploration, and they try to honor the laws of physics. I watched the Gregory Peck movie 'Marooned' over and over when I was a kid.

I grew up in a little town in Minnesota, 500 people. I went out to Princeton, and I wasn't very well-accepted out there by the fancy folks of Princeton University, I felt. I came away bruised and feeling rejected.