To retain my fascination with chemistry, I have had to change my research fields about every 10 years.

This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.

An investigator starts research in a new field with faith, a foggy idea, and a few wild experiments. Eventually the interplay of negative and positive results guides the work. By the time the research is completed, he or she knows how it should have been started and conducted.

We usually don't have applications in mind. They come later.

To retain my fascination with chemistry, I have had to change my research fields about every 10 years.

By the time I entered college, I had decided not to have children, a decision that was never regretted. Accordingly, I was careful to court only girls who wanted to have professional careers.

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired.

We used to think that revolutions are the cause of change. Actually it is the other way around: change prepares the ground for revolution.

I must stress here the point that I appreciate clarity, order, meaning, structure, rationality: they are necessary to whatever provisional stability we have, and they can be the agents of gradual and successful change.

Excuses change nothing, but make everyone feel better.

So, first you have to be able to play with a metronome. Then you take your freedom. If you play in an orchestra, you got to watch the conductor, he is like a metronome, but it is more difficult because he can change rhythms.

I wouldn't change Buffy for anything and I wouldn't change the course in which she has evolved but it is nice to be able to do something that is a little different.

For example, UNICEF works with governments to change legislation such as in India where a law was passed raising the age of compulsory school completion to keep children in school and away from the workplace for longer.

Great joy, especially after a sudden change of circumstances, is apt to be silent, and dwells rather in the heart than on the tongue.

I still feel that a movie has to attempt to say something - even if it fails miserably. But I've sort of given up on believing that I'm going to change the world with every film I choose to act in.

Don't knock the weather; nine-tenths of the people couldn't start a conversation if it didn't change once in a while.

You don't have to be the Dalai Lama to tell people that life's about change.

I knew that my staying up would not change the election result if I were defeated, while if elected I had a hard day ahead of me. So I thought a night's rest was best in any event.

It will always be a battle a day between those who want maximum change and those who want to maintain the status quo.

Being a father, well, I don't know if this is a change, but it makes me want to get out of here faster. Get off the clock. Just 'cause the baby is my reason for living, my reason for coming to work.

A liberal knows that the only certainty in this life is change but believes that the change can be directed toward a constructive end.

I was born not knowing and have had only a little time to change that here and there.

In their search for quality, people seem to be looking for permanency in a time of change.

The game has kept faith with the public, maintaining its old admission price for nearly thirty years while other forms of entertainment have doubled and tripled in price. And it will probably never change.

One day I actually took the list into the bathroom and I put it up against my face and looked in the mirror and I realized I had one of two choices, change the list or change myself.

But the real focus should be on people who are buying today because the base is so big it will take a long time for any change materialize on an overall basis.

Markets change, tastes change, so the companies and the individuals who choose to compete in those markets must change.

The psychological basis of the metropolitan type of individuality consists in the intensification of nervous stimulation which results from the swift and uninterrupted change of outer and inner stimuli.

Headteachers and governing bodies run schools and that won't change.

Using the power of decision gives you the capacity to get past any excuse to change any and every part of your life in an instant.

They said just keep doing my thing, don't try to change anything, which I won't.

Change can either challenge or threaten us. Your beliefs pave your way to success or block you.

My greatest challenge has been to change the mindset of people. Mindsets play strange tricks on us. We see things the way our minds have instructed our eyes to see.

Perhaps it's the people whose lives have taken sudden new twists - people who have learned to embrace the creative possibilities of change - who stand the best chance of penetrating life's mysteries.

It is not necessary to change. Survival is not mandatory.

Change is not a destination, just as hope is not a strategy.

Success, for me, is being able to provide information that will help to change someone's life positively.

I think we can be the very best place to start a business, to grow a business, to invent a new technology, to change the world, to change the country. But we've got a lot of work to deliver a new California to the people of California.

An organization's reason for being, like that of any organism, is to help the parts that are in relationship to each other, to be able to deal with change in the environment.

In order to change unwanted habits and actions, it is important to take the time to get to know yourself.

I'm a former hippie, so clothes are important to me - your clothes defined you in that period. I guess clothes still defines people. But, I change a lot. I'm in my Brooks Brothers period now.

Jealousy is bred in doubts. When those doubts change into certainties, then the passion either ceases or turns absolute madness.

Wisdom lies neither in fixity nor in change, but in the dialectic between the two.

I'm gonna try and change the course of hip hop again.

I tend to arrive in the rehearsal process with very strongly developed ideas about what I want to do. But I don't like those ideas to be things that are not subject to change, or subject to development, or subject to challenge.

A great attitude does much more than turn on the lights in our worlds; it seems to magically connect us to all sorts of serendipitous opportunities that were somehow absent before the change.

Accidents, try to change them - it's impossible. The accidental reveals man.

Policies are many, Principles are few, Policies will change, Principles never do.

We must remember that one determined person can make a significant difference, and that a small group of determined people can change the course of history.