All I ever promised was that I was sure I could develop a new pharmacological agent which might answer a physiological question. Any utility would be implicit in that answer.

My father, a mining engineer and colliery manager, gave his brood many advantages not least of which, for me, was his love of singing which gave music a central place in our lives.

All I ever promised was that I was sure I could develop a new pharmacological agent which might answer a physiological question. Any utility would be implicit in that answer.

I met Hilary Vaughan at a Student Ball in 1944 and we married in the summer of 1946, as soon as I graduated.

In teaching, I wanted to offer a general pharmacology course based on chemical principles, biochemical classification and mathematical modelling. In the event I achieved neither of my ambitions.

The Wellcome Foundation offered me the chance to establish a small academic research unit, modestly funded, but with total independence. The real opportunity, however, came from King's College, London.

During my six years with them Dr Garnet Davey (subsequently Research Director) constantly supported me and, I have no doubt, fought many battles on my behalf to keep the initially controversial programme going.

Half-jokingly, I asked what was wrong with me. So we made a deal: I would run his biological research provided I had a free hand to run my new project.

Apart from two periods of intense study, of music between the ages of 12 and 14 and of mathematics between the ages of 14 and 16, I coasted, daydreaming, through most of my school years.

The outcome, the fourth in an issue of five boys born into a staunch Baptist home, meant that from the beginning I was taught to be respectful of others no less than myself, influencing ever since both my political and administrative attitudes.

I had found myself a new mission - and once more my recurring dilemma between corporate commercial needs and personal scientific ambitions was solved unexpectedly.

We paid off our debts, we learned some, made friends and returned in 1950 with a larger view of life. I had, however, no home, no income of any kind and no prospects whatsoever.

I did help to set up an undergraduate course in medicinal chemistry and made progress in modelling and analysing pharmacological activity at the tissue level, my new passion.

There are two sides to every question.

You look at the whole Human Rights questions, I happened to be there at just the right time when the country was awakening - this goes to the first question you asked - the whole country was awakening to a hundred years of injustice that hadn't been resolved yet.

So, for example, a country was into recession right after I was sworn in, a dot-com bust had taken place. Then the attacks of September the 11th, and then of course the great financial meltdown in the -the fundamental question facing any presidency is how do you deal with the hand you're dealt?

If not for music, I would probably be a very frustrated scientist. It's one way to answer the question, 'What is the meaning of life?' I feel music answers it better.

Did you hear that? I didn't hear anything. Put that question another way.

If you do not know how to ask the right question, you discover nothing.

The real question isn't whether you love your kids or not, but how well you are able to demonstrate your love and caring so that your children really feel loved.

There is no question that everybody who works in show business is lucky because of the number of people who wish they where working in show business.

A single question can be more influential than a thousand statements.

He said there is 80 of us, ready to come down and the next thing I knew is that Jo Brown dashed in and said your family has already moved and you have to move, the boat is ready to take you out. I didn't have time to ask, even ask a question.

So begins a question which has of late become more and more urgent: what is the relation of aesthetics to politics?

When artists make art, they shouldn't question whether it is permissible to do one thing or another.

There's another issue here - and I have some limits as to what I can say - but there's some real question as to the viability of the chemical masks, the protective gear used by our soldiers.

This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.

In mathematics the art of proposing a question must be held of higher value than solving it.

The question is: Where would it get you if something that's a little bit ambiguous in the movie is made clear? It doesn't get you anywhere.

Well, WorldCom's growth exploded in the Clinton years, there's no question, there's no disputing that.

Fix reason firmly in her seat, and call to her tribunal every fact, every opinion. Question with boldness even the existence of a God; because, if there be one, he must more approve of the homage of reason, than that of blindfolded fear.

People of little understanding are most apt to be angry when their sense is called into question.

By asking a novel question that you don't know the answer to, you discover whether you can formulate a way of finding the answer, and you stretch your own mind, and very often you learn something new.

Slavery is not the only question which comes up in this controversy. There is a far more important one to you, and that is, what shall be done with the free negro?

Will dissent be permitted? The answer to that question will determine whether the society is a free society or a fear society.

Faulkner turned out to be a great teacher. When a student asked a question ineptly, he answered the question with what the student had really wanted to know.

The question was heatedly debated of how much Western culture should be brought into China.

Rock and roll doesn't necessarily mean a band. It doesn't mean a singer, and it doesn't mean a lyric, really. It's that question of trying to be immortal.

Nature puts no question and answers none which we mortals ask. She has long ago taken her resolution.

God willing, we shall come to a stage where the world looks at the Palestinian question, and Palestinian rights on Palestinian national soil, as well as the questions of the occupied Syrian and Lebanese territories. These are the bases on which peace will be built.

Asked at the hearing why she hadn't pressed the FBI more closely about what it knew, or didn't know, about domestic terrorist threats, Rice acted as though the question was an odd one: it wasn't her job. Well, in retrospect, it was and now certainly is.

When the problems in Northern Ireland started, it was not a question of Protestantism or Catholicism, because the Catholic church was the only church at that time-it was a nationalist conflict.

The question arises whether all lawyers are the same. This is like asking whether everything that gets into a sewer is garbage.

I deem it established, then, that the Constitution does not recognize property in man, but leaves that question, as between the states, to the law of nature and of nations.

The gift of broadcasting is, without question, the lowest human capacity to which any man could attain.

Instead of asking 'How much damage will the work in question bring about?' why not ask 'How much good? How much joy?'

Will we fight or will we retreat? That is the question that is posed to us. Some of my friends on the other side of the aisle often refer to Iraq as a distraction.

At a Boston signing, someone from the audience asked why I was so obsessed with furniture in my books. The question rattled around in my head. I had no idea that I was obsessed with furniture.

The way to develop decisiveness is to start right where you are, with the very next question you face.