The Wellcome Foundation offered me the chance to establish a small academic research unit, modestly funded, but with total independence. The real opportunity, however, came from King's College, London.

My father, a mining engineer and colliery manager, gave his brood many advantages not least of which, for me, was his love of singing which gave music a central place in our lives.

All I ever promised was that I was sure I could develop a new pharmacological agent which might answer a physiological question. Any utility would be implicit in that answer.

I met Hilary Vaughan at a Student Ball in 1944 and we married in the summer of 1946, as soon as I graduated.

In teaching, I wanted to offer a general pharmacology course based on chemical principles, biochemical classification and mathematical modelling. In the event I achieved neither of my ambitions.

The Wellcome Foundation offered me the chance to establish a small academic research unit, modestly funded, but with total independence. The real opportunity, however, came from King's College, London.

During my six years with them Dr Garnet Davey (subsequently Research Director) constantly supported me and, I have no doubt, fought many battles on my behalf to keep the initially controversial programme going.

Half-jokingly, I asked what was wrong with me. So we made a deal: I would run his biological research provided I had a free hand to run my new project.

Apart from two periods of intense study, of music between the ages of 12 and 14 and of mathematics between the ages of 14 and 16, I coasted, daydreaming, through most of my school years.

The outcome, the fourth in an issue of five boys born into a staunch Baptist home, meant that from the beginning I was taught to be respectful of others no less than myself, influencing ever since both my political and administrative attitudes.

I had found myself a new mission - and once more my recurring dilemma between corporate commercial needs and personal scientific ambitions was solved unexpectedly.

We paid off our debts, we learned some, made friends and returned in 1950 with a larger view of life. I had, however, no home, no income of any kind and no prospects whatsoever.

I did help to set up an undergraduate course in medicinal chemistry and made progress in modelling and analysing pharmacological activity at the tissue level, my new passion.

Every American deserves to live in freedom, to have his or her privacy respected and a chance to go as far as their ability and effort will take them - regardless of race, gender, ethnicity or economic circumstances.

There is a very good chance I could have been a screw-up for the rest of my life.

Anytime you have a difficult encounter with your child, there is a good chance that at least one of these factors is bringing out the worst in him or her: transitions, time pressure, competition for your attention, conflicting objectives.

All anyone asks for is a chance to work with pride.

Chance, my dear, is the sovereign deity in child-bearing.

The Round-Up is a wonderful community celebration, and I greatly enjoy the chance to visit with residents and see so many families enjoying the festivities offered throughout the week.

But, in the name of the experimental method and out of our poor knowledge, are we really entitled to claim that everything happens by chance, to the exclusion of all other possibilities?

If I had had a chance to tour with Van Halen before the record, I think it would have been a different record.

And at the same time, you are of course a performer, but it's very important that you understand that your role as a performer is to get the best performance from those wonderful colleagues that you have the chance to work with.

All of us who are convinced that our military needs all the support the government and public will provide are pleased that he will have his chance to do just that.

All my pictures are built around the idea of getting in trouble and so giving me the chance to be desperately serious in my attempt to appear as a normal little gentleman.

Networks decide who will have a chance to do shows, but it is the viewers who make the final decision of who stays and who goes. I am very fortunate, in that the television viewers of our country have decided that Bob Barker can stay.

I've spent my career trying to help people without connections understand what's going on so that they have a chance of getting a fair shake from the connected and the powerful.

Detroit was kind of a random thing where it was like a chance to be in a rock 'n' roll movie.

I haven't really had that many opportunities to play "lead" so I guess I jumped at the chance. I have also never done any "sci-fi" projects and thought it might be fun.

The records fell easily at first. Dozens of seconds peeled away with every running of a course, and I could hardly wait for the next chance to improve.

With two small children, I haven't had a wash since 2001 so the chance to go shopping is way down the list. It is something I do intend to get.

Also, when I started racing he knew a lot of people and it was more easy for me to find the first bike, so I have a good chance for sure.

Perhaps it's the people whose lives have taken sudden new twists - people who have learned to embrace the creative possibilities of change - who stand the best chance of penetrating life's mysteries.

When you suffer an attack of nerves you're being attacked by the nervous system. What chance has a man got against a system?

I know Mama Rose is a great role and I love having a chance to do it.

Chance gives rise to thoughts, and chance removes them; no art can keep or acquire them.

Whenever we have thanked these men and women for what they have done for us, without exception they have expressed gratitude for having the chance to help - because they grew as they served.

So, it takes a lot of chance and luck. I mean I was lucky enough to get in the program where people with the same skills never made it to the program. So keep trying.

Equal opportunity means everyone will have a fair chance at being incompetent.

When it's your chance to step up to the plate, just hit it out of the park, and everybody will forget about everything that came before.

Welcome, wild harbinger of spring! To this small nook of earth; Feeling and fancy fondly cling, Round thoughts which owe their birth, To thee, and to the humble spot, Where chance has fixed thy lowly lot.

I was notified on July 17 to be ready to start August 7 for an October air date. When we reached the screen we did not have a single segment ready. It was done so fast the writers never got a chance to know what it was all about.

We have to say now we think the character of the party has changed so far it will take something very exceptional, something really out of the ordinary line to make us be convinced there's a chance of winning back the party.

It takes but one positive thought when given a chance to survive and thrive to overpower an entire army of negative thoughts.

It makes a difference what we choose to experience during sleep. Many of us think of sleep as a chance to get away from it all. But sleep is also a chance to return to the joys of our spiritual heritage - our universal awareness.

Releasing a record is only the tip of the iceberg when it comes to the promotion of the product, but you have to play the game if you are to have a chance of competing in the market place.

A person who has not done one half his day's work by ten o clock, runs a chance of leaving the other half undone.

Chance happens to all, but to turn chance to account is the gift of few.

Give us a chance to show you that those so-called protective laws to aid women - however well intentioned originally - have become in fact restraints, which keep wife, abandoned wife, and widow alike from supporting her family.

When someone saves your life and gives you life, there's gratitude, humility; there's a time you've been so blessed you realize you've been given another chance at life that maybe you did or didn't deserve.